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Contributor Information

  • Name Bernhard B. Singer
  • Institute LeukoCom

Tool Details

  • Tool name: Anti-CEACAM6 (CD66c) [1H7-4B]
  • Alternate names: CD66c
  • Clone: 1H7-4B
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Digestive / Gastrointestinal cancer
  • Molecular weight of the target: 90 kDa
  • Application: ELISA ; FACS ; IHC ; WB
  • Strain: Balb/c
  • Description: CEACAM6 is a glycosyl phosphatidyl inositol (GPI) linked glycoprotein. CEACAM6 expression is upregulated in many adenocarcinomas and leukemias. CEACAM6 is expressed in epithelial cells of the fetal and adult gastrointestinal tract, epithelia of glandular tissues, squamous epithelial cell of the tongue, esophagus and cervix as well as on granulocytes.
  • Immunogen: Recombinant human CEACAM6 extracellular domain.
  • Isotype: IgG1 kappa
  • Research area: Immunology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: CEACAM6, CD66c
  • Target molecular weight: 90 kDa
  • Target background: CEACAM6 is a glycosyl phosphatidyl inositol (GPI) linked glycoprotein. CEACAM6 expression is upregulated in many adenocarcinomas and leukemias. CEACAM6 is expressed in epithelial cells of the fetal and adult gastrointestinal tract, epithelia of glandular tissues, squamous epithelial cell of the tongue, esophagus and cervix as well as on granulocytes.

Application Details

  • Application: ELISA ; FACS ; IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -80°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Singer et al. 2014. PLoS One. 9(4):e94106. PMID: 24743304.
  • •  Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses.
  • •  Muturi et al. 2013. PLoS One. 8(9):e74654. PMID: 24040308.
  • •  Tumor and endothelial cell-derived microvesicles carry distinct CEACAMs and influence T-cell behavior.
  • •  Klaile et al. 2013. Respir Res. 14:85. PMID: 23941132.
  • •  Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II int