ANTIBODIES
Contributor Information
- Name Ayham Alnabulsi
- Institute Absolute Antibody ; Vertebrate Antibodies Limited
Tool Details
- Tool name: Anti-PDL2 (soluble form) [Z64P2D3*H4] rAb
- Alternate names: B7 dendritic cell molecule, B7-DC, B7DC, bA574F11.2, Btdc, Butyrophilin B7 DC, Butyrophilin B7-DC, Butyrophilin B7DC, CD 273, CD273, CD273 antigen, MGC142238, MGC14224, PD 1 ligand 2, PD L2, PD-1 ligand 2, PD-L2, PD1 ligand 2, PD1L2_HUMAN, PDCD 1 ligand 2, PDCD1 ligand 2
- Clone: Z64P2D3*H4
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Recombinant
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IHC ; WB
- Description: Recombinant antibody of PDL2 which can aid understanding of programmed death ligand 2, in the secreted form. Background and Research Application PDL2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.). PDL2 is an immune checkpoint receptor ligand which plays a role in negative regulation of the adaptive immune response.PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1). This is a recombinant version of the anti-PDL2 monoclonal antibody . PD-1, is a key immune checkpoint. Currently several anti-PD-1 antibodies or blockers are in cancer clinical trials and showing promising outcomes. This antibody will allow scientists examine, for the first time, the clinical significance of PDL2-secreted form.
- Immunogen: Ovalbumin-conjugated synthetic peptide KAVFFKRHN
- Immunogen UniProt ID: Q9BQ51
- Isotype: Not Known
- Research area: Immunology
- For Research Use Only
Target Details
- Target: Programmed Cell Death 1 Ligand 2 (PDL2-Soluble form)
- Target background: Recombinant antibody of PDL2 which can aid understanding of programmed death ligand 2, in the secreted form. Background and Research Application PDL2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.). PDL2 is an immune checkpoint receptor ligand which plays a role in negative regulation of the adaptive immune response.PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1). This is a recombinant version of the anti-PDL2 monoclonal antibody. PD-1, is a key immune checkpoint. Currently several anti-PD-1 antibodies or blockers are in cancer clinical trials and showing promising outcomes. This antibody will allow scientists examine, for the first time, the clinical significance of PDL2-secreted form.
Application Details
- Application: ELISA ; IHC ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS
- Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Shipping at 4° C
Documentation
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