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Contributor Information

  • Name Nancy Hogg
  • Institute Absolute Antibody ; Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-CD8 [14] rAb
  • Alternate names: Leu2
  • Clone: 14
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Recombinant
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; FACS ; IHC ; IP ; WB
  • Description: CD8 is a T cell co-receptor that recognises, together with the T cell receptor, MHC class I molecules. CD8 is present on human suppressor / cytotoxic T cells, 30% of circulating T cells. Clone 14 is recommended for: the detection of immunoregulatory T cell subset imbalances in autoimmune disorders and immunodeficiency states, categorisation of T cell acute lymphoblastic leukaemia and lymphoblastic lymphoma in conjunction with other antigens and determination of CD4/CD8 ratios in immune deficiencies, rheumatoid arthritis and multiple sclerosis.
  • Immunogen: Fibronectin-purified human monocytes
  • Isotype: IgG1
  • Research area: Immunology

  • For Research Use Only

Target Details

  • Target: CD8
  • Target background: CD8 is a T cell co-receptor that recognises, together with the T cell receptor, MHC class I molecules. CD8 is present on human suppressor / cytotoxic T cells, 30% of circulating T cells. Clone 14 is recommended for: the detection of immunoregulatory T cell subset imbalances in autoimmune disorders and immunodeficiency states, categorisation of T cell acute lymphoblastic leukaemia and lymphoblastic lymphoma in conjunction with other antigens and determination of CD4/CD8 ratios in immune deficiencies, rheumatoid arthritis and multiple sclerosis.

Application Details

  • Application: ELISA ; FACS ; IHC ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS
  • Shipping conditions: Shipping at 4° C

Documentation

References

  •   Original hybridoma first published in: Hogg et al. 1999. J Clin Invest. 103(1):97-106. PMID: 9884339.