ANTIBODIES

Contributor Information
- Name Nancy Hogg
- Institute Absolute Antibody ; Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
- Tool name: Anti-CD8 [14] rAb
- Alternate names: Leu2
- Clone: 14
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Recombinant
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; FACS ; IHC ; IP ; WB
- Description: CD8 is a T cell co-receptor that recognises, together with the T cell receptor, MHC class I molecules. CD8 is present on human suppressor / cytotoxic T cells, 30% of circulating T cells. Clone 14 is recommended for: the detection of immunoregulatory T cell subset imbalances in autoimmune disorders and immunodeficiency states, categorisation of T cell acute lymphoblastic leukaemia and lymphoblastic lymphoma in conjunction with other antigens and determination of CD4/CD8 ratios in immune deficiencies, rheumatoid arthritis and multiple sclerosis.
- Immunogen: Fibronectin-purified human monocytes
- Isotype: IgG1
- Research area: Immunology
- For Research Use Only
Target Details
- Target: CD8
- Target background: CD8 is a T cell co-receptor that recognises, together with the T cell receptor, MHC class I molecules. CD8 is present on human suppressor / cytotoxic T cells, 30% of circulating T cells. Clone 14 is recommended for: the detection of immunoregulatory T cell subset imbalances in autoimmune disorders and immunodeficiency states, categorisation of T cell acute lymphoblastic leukaemia and lymphoblastic lymphoma in conjunction with other antigens and determination of CD4/CD8 ratios in immune deficiencies, rheumatoid arthritis and multiple sclerosis.
Application Details
- Application: ELISA ; FACS ; IHC ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS
- Shipping conditions: Shipping at 4° C
Related Tools
References
- • Original hybridoma first published in: Hogg et al. 1999. J Clin Invest. 103(1):97-106. PMID: 9884339.