ANTIBODIES

Contributor Information
- Name Walter Bodmer
- Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
- Tool name: Anti-C3 [WM1]
- Clone: WM1
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: Fn ; IP
- Strain: Balb/c
- Description: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
- Immunogen: Human complement component 3
- Isotype: IgG1 lambda
- Research area: Cell biology; Immunology; Neurobiology; Biochemistry
- Myeloma used: P3X63Ag8
- For Research Use Only
Target Details
- Target: Human complement component 3
- Target background: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Application Details
- Application: Fn ; IP
Handling
- Format: Liquid
- Shipping conditions: Shipping at 4ðC
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References
- • Whitehead et al. 1981. Eur J Immunol. 11(2):140-6. PMID: 6163641.
- • A monoclonal antibody against human complement component C3: the production of C3 by human cells in vitro.