ANTIBODIES
Contributor Information
- Name Roy Jefferis
- Institute University of Birmingham
Tool Details
- Tool name: Anti-CD45RA [BU77]
- Alternate names: PTPRC, CD45RA
- Clone: BU77
- Tool type: Antibodies
- Tool sub-type: Primary Antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Cancer type: Blood cancer
- Application: FACS ; IHC
- Strain: Balb/c
- Description: CD45RA is a transmembrane tyrosine phosphatase that is present on all leukocytes. CD45 RA regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45 can be expressed as one of several isoforms by alternative splicing of exons that comprise the extracellular domain. CD45RA is expressed on na??ve T cells, as well as the effector cells in both CD4 and CD8. CD45RA is an isoform of the PTPRC complex which is selectively expressed on B cells.
- Immunogen: Perpheral Blood B cells
- Isotype: IgG2a
- Research area: Cell biology; Immunology; Stem cell biology
- Myeloma used: P3X63Ag8.653
- For Research Use Only
Target Details
- Target: Protein tyrosine phosphatase receptor type C
-
Target background: CD45RA is a transmembrane tyrosine phosphatase that is present on all leukocytes. CD45 RA regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45 can be expressed as one of several isoforms by alternative splicing of exons that comprise the extracellular domain. CD45RA is expressed on na
ve T cells, as well as the effector cells in both CD4 and CD8. CD45RA is an isoform of the PTPRC complex which is selectively expressed on B cells.
Application Details
- Application: FACS ; IHC
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
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