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Contributor Information

  • Name Jacqueline Cordell
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-Von Willebrand Factor [F8/86] mAb
  • Clone: F8/86
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; WB
  • Description: Von Willebrand factor (vWF) mediates platelet adhesion to injured endothelium, the first step in hemostasis, and helps maintain factor VIII levels. When vWF is deficient, patients have a bleeding disorder called von Willebrand disease (vWD).
  • Immunogen: Von Willebrand factor isolated from human plasma
  • Isotype: IgG1
  • Research area: Tissue-specific biology; Stem cell biology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Factor VIII-related antigen (Von Willebrand factor / vWf)
  • Target background: Von Willebrand factor (vWF) mediates platelet adhesion to injured endothelium, the first step in hemostasis, and helps maintain factor VIII levels. When vWF is deficient, patients have a bleeding disorder called von Willebrand disease (vWD).

Application Details

  • Application: IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

Documentation

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References

  • •  Ellis et al. 2012. J Oncol. 2012:651507. PMID: 22545050.
  • •  Angiogenesis in Paget's Disease of the Vulva and the Breast: Correlation with Microvessel Density.
  • •  Hussein et al. 2009. Leukemia. 23(5):852-5. PMID: 19194467.
  • •  MPLW515L mutation in acute megakaryoblastic leukaemia.
  • •  Disse et al. 2009. Blood. 113(4):973-80. PMID: 18945966.
  • •  Phospholipase D1 is specifically required for regulated secretion of von Willebrand factor from endothelial cells.