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Contributor Information

  • Name Ayham Alnabulsi
  • Institute Vertebrate Antibodies Limited

Tool Details

  • Tool name: Anti-activated MMP1 [5C10]
  • Alternate names: actMMP-1, actMMP1, activated-MMP1, activated MMP1, activated-MMP-1, activated MMP-1, Fibroblast collagenase
  • Clone: 5C10
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 40 kDa
  • Application: WB
  • Strain: Balb/c
  • Description: Matrix metalloproteinases (MMPs) are synthesized as inactive zymogens with a pro-peptide domain that must be removed before the enzyme is active. MMP1 breaks down the interstitial collagens, types I, II, and III hence it is an important feature of development, morphogenesis, tissue repair and remodeling. The anti-activated MMP1 [clone 5C10] antibody specifically targets the active form of MMP1 and is suitable for western blot only; it does not cross-react with proenzyme MMP1, or proenzyme or active forms of MMP2, MMP3 and MMP9.
  • Immunogen: Ovalbumin-conjugated synthetic peptide; FVLTEGNPRC
  • Isotype: IgG1 kappa
  • Research area: Cancer; Tissue-specific biology; Cell signaling and signal transduction
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: activated human matrix metalloproteinase 1 (MMP1)
  • Target molecular weight: 40 kDa
  • Target background: Matrix metalloproteinases (MMPs) are synthesized as inactivezymogenswith a pro-peptide domain that must be removed before theenzymeis active.MMP1 breaks down the interstitialcollagens, types I, II, and III hence itis an important feature of development, morphogenesis, tissue repair andremodeling. The anti-activated MMP1 [clone 5C10] antibody specifically targets the active form of MMP1 and is suitable for western blot only; it does not cross-react with proenzyme MMP1, or proenzyme or active forms of MMP2, MMP3 and MMP9.

Application Details

  • Application: WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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