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Contributor Information

  • Name Irene Leigh
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-Keratin 1 [LL017]
  • Clone: LL017
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; IHC
  • Description: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 1 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epthelia. Mutations in keratin 1 causes epidermolytic hyperkeratosis. LL017 does not react with any tumour tissue regardless of histological classification.
  • Immunogen: Synthetic peptide - VSTTYSGVTR
  • Isotype: IgM
  • Research area: Cell signaling and signal transduction
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Keratin 1, Cytokeratin 1
  • Target background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 1 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epthelia. Mutations in keratin 1 causes epidermolytic hyperkeratosis. LL017 does not react with any tumour tissue regardless of histological classification.

Application Details

  • Application: IHC ; IHC

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  de Berker et al. 1995. Exp Dermatol. 4(6):350-6. PMID: 8608342.
  • •  Keratin expression in discoid lupus erythematosus.
  • •  Leigh et al. 1993. Br J Dermatol. 129(2):110-9. PMID: 7544603.
  • •  Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation.
  • •  Markey et al. 1992. Br J Dermatol. 126(2):154-60. PMID: 1371396.
  • •  Keratin expression in basal cell carcinomas.
  • •  Ishida-Yamamoto et al. 1991. J Invest Dermatol. 97(6):959-68. PMID: 1721080.
  • •  Epidermolysis bullosa simplex (Dowling-Meara type) is a genetic disease characterized by an abnormal keratin-filament network involving keratins K5 and K14.