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Anti-Cathepsin L [4C11]

Cat. #152642

Tool name: Anti-Cathepsin L [4C11]
Clone: 4C11
Tool type: Antibodies
Tool sub-type: Primary antibody
Class: Monoclonal
Conjugate: Unconjugated
Reactivity: Human
Host: Mouse
Application: IF ; WB
Description: Cathepsin L is expressed in most cells but in a higher level in cancerous cells. Normal levels of cathepsin L is involved in the regulation of epithelial cell proliferation and differentiation in the skin. It is recognized that many cancer cells secrete cathepsin L to degrade the components of extracellular matrices and basement membranes. This promotes tumor invasion and metastasis. The pro-form of cathepsin L exists as a molecular size of 50kDa. The pro-form could be degraded and secreted out as two smaller forms of cathepsin L. These smaller forms are known as the mature forms. The pro-forms and mature forms are secreted out of the healthy cells. However, there is a significant increase in levels of pro-forms that are secreted out of the cancerous cells. Monoclonal antibodies generated against pro-form of cathepsin L would be useful for diagnostic purposes.
Immunogen: GST-HCL fusion protein
Isotype: IgM
Research area: Cell biology; Cancer; Cell signaling and signal transduction; Neurobiology; Biochemistry
Myeloma used: Sp2/0-Ag14

Target: Cathepsin L, HCL
Target background: Cathepsin L is expressed in most cells but in a higher level in cancerous cells. Normal levels of cathepsin L is involved in the regulation of epithelial cell proliferation and differentiation in the skin. It is recognized that many cancer cells secrete cathepsin L to degrade the components of extracellular matrices and basement membranes. This promotes tumor invasion and metastasis. The pro-form of cathepsin L exists as a molecular size of 50kDa. The pro-form could be degraded and secreted out as two smaller forms of cathepsin L. These smaller forms are known as the mature forms. The pro-forms and mature forms are secreted out of the healthy cells. However, there is a significant increase in levels of pro-forms that are secreted out of the cancerous cells. Monoclonal antibodies generated against pro-form of cathepsin L would be useful for diagnostic purposes.

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