Product Image

Contributor Information

  • Institute A*STAR Accelerate Technologies Pte Ltd

Tool Details

  • Tool name: Anti-Beta3 [7D1]
  • Clone: 7D1
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cell signalling pathway: Calcium signalling
  • Application: FACS ; IF ; WB
  • Description: Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omegaagatoxin-IVA (omega-aga-IVA). The overall conclusion is that deletion of the beta 3 subunit affects at least three distinct types of High voltage activated Ca2+ channel (L,N and P/Q types), but no single type of channel is solely dependent on beta 3. The beta3 (Î?3) subunit of high-voltage-gated calcium channels is a peripheral membrane protein that co-purifies with neural N-type calcium channels. Beta3 subunit contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating g protein inhibition and controlling the alpha-1 subunit membrane targeting.
  • Immunogen: GST-beta3 fusion protein
  • Isotype: IgG1
  • Research area: Genetics; Neurobiology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Beta3 subunit of high-voltage-gated calcium channel
  • Target background: Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omegaagatoxin-IVA (omega-aga-IVA). The overall conclusion is that deletion of the beta 3 subunit affects at least three distinct types of High voltage activated Ca2+ channel (L,N and P/Q types), but no single type of channel is solely dependent on beta 3. The beta3 (?3) subunit of high-voltage-gated calcium channels is a peripheral membrane protein that co-purifies with neural N-type calcium channels. Beta3 subunit contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating g protein inhibition and controlling the alpha-1 subunit membrane targeting.

Application Details

  • Application: FACS ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

Related Tools

Product Image

Anti-IgM [Z68 P2B8*D4]

#158033
Product Image

Anti-RA056/11.76.1 [11.76.1]

#160523
Product Image

Anti-HLADQ1 [TAL 4.1]

#151228