ANTIBODIES
Contributor Information
- Name Ayham Alnabulsi
- Institute Vertebrate Antibodies Limited
Tool Details
- Tool name: Anti-RUNX3 [K12P3F11*C9]
- Clone: K12P3F11*C9
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Molecular weight of the target: 44 kDa
- Application: ELISA ; IHC ; WB
- Description: Runx3 (also known as AML2 and CBF alpha 3) forms a heterodimer with a beta subunit. The complex binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
- Immunogen: Peptide QFDRSFPTL
- Isotype: IgG1 kappa
- Research area: Genetics
- Myeloma used: P3X63Ag8.653
- For Research Use Only
Target Details
- Target: Runt-related transcription factor 3
- Target molecular weight: 44 kDa
- Target background: Runx3 (also known as AML2 and CBF alpha 3) forms a heterodimer with a beta subunit. The complex binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Application Details
- Application: ELISA ; IHC ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
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