Product Image

Contributor Information

  • Name Ayham Alnabulsi
  • Institute Vertebrate Antibodies Limited

Tool Details

  • Tool name: Anti-Cytochrome P450 27A1 [V29-P4B8*B2]
  • Clone: V29-P4B8*B2
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; WB ; ELISA ; IHC ; WB
  • Description: Cytochrome P450 27A1 (CYP27A1) catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity.
  • Immunogen: Ovalbumin-conjugated synthetic peptide KVVLAPETGEL (C-terminal sequence)
  • Isotype: IgG1 kappa
  • Research area: Cancer; Tissue-specific biology; Cell signaling and signal transduction; Metabolism

  • For Research Use Only

Target Details

  • Target: Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1), Sterol 27-Hydroxylase
  • Target background: Cytochrome P450 27A1 (CYP27A1) catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity.

Application Details

  • Application: IHC ; WB ; ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -20°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.
  •   Swan et al. 2016. Oncotarget. :. PMID: 27341022.