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Contributor Information

  • Name Martin Humphries
  • Institute University of Manchester

Tool Details

  • Tool name: Anti-CD29 [8E3]
  • Alternate names: Integrin Subunit Beta 1; Glycoprotein Iia; MSK12; GPIIA; FNRB; MDF2; Very Late Activation Protein; Beta Polypeptide; Fibronectin Receptor Subunit Beta; Integrin VLA-4 Beta Subunit; CD29 Antigen; VLA-BETA; CD29; VLAB
  • Clone: [8E3]
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC ; IP ; WB
  • Description: Integrin beta1 (CD29) is a transmembrane glycoprotein that forms noncovalent complexes with various alpha integrin subunits to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. Interactions between integrins and extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Phosphorylation of threonines 788 and 789 on integrin beta1 receptor may play a key role in cell-cycle dependent regulation.
  • Immunogen: Purified Integrin Beta1 from HT-1080 cells.
  • Isotype: IgG1 kappa
  • Research area: Cell biology; Cancer; Cell signaling and signal transduction; Genetics; Immunology

  • For Research Use Only

Target Details

  • Target: Integrin beta-1 (CD29), VLA-4 subunit beta
  • Target background: Integrin beta1 (CD29) is a transmembrane glycoprotein that forms noncovalent complexes with various alpha integrin subunits to form the Fn receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. Interactions between integrins and extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Phosphorylation of threonines 788 and 789 on integrin beta1 receptor may play a key role in cell-cycle dependent regulation.

Application Details

  • Application: ELISA ; IHC ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Tiwari et al. 2011. J Cell Sci. 124(Pt 10):1672-80. PMID: 21511727.
  • •  Divalent cations regulate the folding and activation status of integrins during their intracellular trafficking.
  • •  Bridger et al. 2008. Biol Reprod. 79(2):274-82. PMID: 18417711.
  • •  Integrin activation in bovine placentomes and in caruncular epithelial cells isolated from pregnant cows.
  • •  Mould et al. 2005. J Biol Chem. 280(6):4238-46. PMID: 15557320.
  • •  Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.