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Contributor Information

  • Name Ayham Alnabulsi
  • Institute Vertebrate Antibodies Limited

Tool Details

  • Tool name: Anti-Cytochrome P450 2A6 [RP1.2B4]
  • Clone: RP1.2B4
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: WB
  • Strain: Balb/c
  • Description: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Possesses low phenacetin O-deethylation activity.
  • Immunogen: Human cytochrome P450 CYP2A6
  • Isotype: IgG1 kappa
  • Research area: Cancer; Tissue-specific biology; Cell signaling and signal transduction; Metabolism
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: Cytochrome P450 2A6, CYP2A6
  • Target background: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Possesses low phenacetin O-deethylation activity.

Application Details

  • Application: WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Barnes, T. S. (1987). The generation and characterization of monoclonal antibodies to human cytochrome P450. Ph. D. Thesis. University of Aberdeen.