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Contributor Information

  • Name Stephen West
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-Senataxin [OY11]
  • Clone: OY11
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Rabbit
  • Molecular weight of the target: 303 kDa
  • Application: IP ; WB
  • Description: Defects in Senataxin are the cause of neurodegenerative diseases AOA-2 and ALS4. Senataxin play vital roles in DNA repair and transcription termination. The staining pattern of the antibody is located in the nucleus and chromatin.
  • Immunogen: A mixture of four peptides corresponding to the following amino acid ranges of human Senataxin: aa8-30, aa884-895, aa1173-1192, aa2654-2677
  • Research area: Genetics; Neurobiology

  • For Research Use Only

Target Details

  • Target: Senataxin
  • Target molecular weight: 303 kDa
  • Target background: Defects in Senataxin are the cause of neurodegenerative diseases AOA-2 and ALS4. Senataxin play vital roles in DNA repair and transcription termination. The staining pattern of the antibody is located in the nucleus and chromatin.

Application Details

  • Application: IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl.
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Yce et al. 2013. Mol Cell Biol. 33(2):406-17. PMID: 23149945.
  • •  Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.