Product Image

Contributor Information

  • Name Michaela Frye ; Fiona Watt
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-NSun2 [EF-1]
  • Clone: EF-1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Rabbit
  • Cancer type: Breast cancer
  • Molecular weight of the target: 80 kDa
  • Application: IF ; IP ; WB
  • Description: NSun2 is a cytosine-5 RNA methyltransferase of transfer RNAs (tRNAs) and other non-coding RNAs. NSun2 is expressed in various tissues, including skin, brain and testis. Expression of Nsun2 is up-regulated in many tumours.
  • Immunogen: NSun2 (Misu) peptides conjugated with keyhole limpet hemocyanin
  • Research area: Genetics

  • For Research Use Only

Target Details

  • Target: NSun2 (Misu)
  • Target molecular weight: 80 kDa
  • Target background: NSun2 is a cytosine-5 RNA methyltransferase of transfer RNAs (tRNAs) and other non-coding RNAs. NSun2 is expressed in various tissues, including skin, brain and testis. Expression of Nsun2 is up-regulated in many tumours.

Application Details

  • Application: IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: Whole serum
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

Related Tools

Product Image

Anti-6His Tag [8F9]

#153500
Product Image

Anti-CD44 [BU52]

#151434
Product Image

Anti-ZNF410 (5E3F9H9)

#161941

References

  • •  Frye et al. 2010. Cancer Lett. 289(1):71-80. PMID: 19740597.
  • •  Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer.
  • •  Hussain et al. 2009. J Cell Biol. 186(1):27-40. PMID: 19596847.
  • •  The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability.
  • •  Frye et al. 2006. Curr Biol. 16(10):971-81. PMID: 16713953.
  • •  The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.