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Contributor Information

  • Name Paul Crocker
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-SIGLEC3 [CD33 1C7/1]
  • Alternate names: Sialic Acid Binding Ig Like Lectin 12; SIGLECL1; SLG 3; Siglec-12; Siglec-L1; S2V
  • Clone: CD33 1C7/1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; WB
  • Description: CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. The protein is also expressed on and a useful marker for peripheral monocytes. It is also useful for distinguishing myelogenous leukaemia cells from lymphoid or erythroid leukaemias.
  • Immunogen: Extracellular portion of CD33 fused to the Fc portion of human IgG1
  • Isotype: IgG1
  • Research area: Cancer; Cell biology; Immunology; Stem cell biology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: CD33
  • Target background: CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. The protein is also expressed on and a useful marker for peripheral monocytes. It is also useful for distinguishing myelogenous leukaemia cells from lymphoid or erythroid leukaemias.

Application Details

  • Application: ELISA ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -80°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Taylor et al. 1999. J Biol Chem. 274(17):11505-12. PMID: 10206955.
  • •  The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2.
  • •  Freeman et al. 1995. Blood. 85(8):2005-12. PMID: 7718872.
  • •  Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules.