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Contributor Information

  • Name Sharon Tooze
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-ATG13 [ATG13]
  • Clone: ATG13
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Rabbit
  • Application: WB
  • Description: Atg13 only binds in the unphosphorylated state, and its dephosphorylation has been shown to be TOR dependent.
  • Immunogen: C-terminal synthetic peptide
  • Research area: Apoptosis and autophagy; Cancer; Cell signaling and signal transduction; Metabolism

  • For Research Use Only

Target Details

  • Target: ATG13
  • Target background: Autophagy has been implicated in a number of medical contexts, such as cancer, neurodegeneration, and immunity. The serine-threonine protein kinase Atg1 was originally identified as a critical autophagy regulator in yeast. Full kinase activity of Atg1 in yeast requires its binding partners Atg13 and Atg17.

Application Details

  • Application: WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Chan et al. 2009. Mol Cell Biol. 29(1):157-71. PMID: 18936157.
  •   Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism.