ANTIBODIES

Contributor Information
- Name Sharon Tooze
- Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
- Tool name: Anti-ATG13 [ATG13]
- Clone: ATG13
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Polyclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Rabbit
- Application: WB
- Description: Atg13 only binds in the unphosphorylated state, and its dephosphorylation has been shown to be TOR dependent.
- Immunogen: C-terminal synthetic peptide
- Research area: Apoptosis and autophagy; Cancer; Cell signaling and signal transduction; Metabolism
- For Research Use Only
Target Details
- Target: ATG13
- Target background: Autophagy has been implicated in a number of medical contexts, such as cancer, neurodegeneration, and immunity. The serine-threonine protein kinase Atg1 was originally identified as a critical autophagy regulator in yeast. Full kinase activity of Atg1 in yeast requires its binding partners Atg13 and Atg17.
Application Details
- Application: WB
Handling
- Format: Liquid
- Shipping conditions: Shipping at 4ðC
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References
- • Chan et al. 2009. Mol Cell Biol. 29(1):157-71. PMID: 18936157.
- • Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism.