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Contributor Information

  • Name Tyson Sharp
  • Institute University College London (UCL)

Tool Details

  • Tool name: Anti-Transmembrane protein [3B5/D7]
  • Clone: 3B5/D7
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Virus
  • Host: Mouse
  • Molecular weight of the target: 50 kDa (full) to 17 kDa
  • Application: ELISA ; IF ; IP ; WB
  • Strain: Balb/c
  • Description: Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the human herpesviruses and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV encodes a distinct open reading frame called K15 at a position equivalent to the gene encoding LMP2A of Epstein-Barr virus (EBV). Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities.
  • Immunogen: Recombinant protein
  • Isotype: IgG1
  • Research area: Apoptosis and autophagy; Biochemistry; Microbiology
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: K15 (putative integral transmembrane protein similar to LMP2A)
  • Target molecular weight: 50 kDa (full) to 17 kDa
  • Target background: Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the human herpesviruses and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV encodes a distinct open reading frame called K15 at a position equivalent to the gene encoding LMP2A of Epstein-Barr virus (EBV). Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities.

Application Details

  • Application: ELISA ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Storage conditions: -80°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Sharp et al. 2002. J Virol. 76(2):802-16. PMID: 11752170.
  • •  K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function.