ANTIBODIES

Contributor Information
- Name Patrick Varga-Weisz
- Institute Marie Curie Research Institute
Tool Details
- Tool name: Anti-SNF2H [SNF2H]
- Clone: SNF2H
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Polyclonal
- Conjugate: Unconjugated
- Reactivity: Human ; Mouse
- Host: Rabbit
- Molecular weight of the target: 121 kDa
- Application: ChIP ; IHC ; IF ; IP ; WB
- Description: SNF2H is a human homolog of the budding yeast Snf2 protein, and is a member of the SWI/SNF family of proteins. The members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. SNF2H is the catalytic subunit of several chromatin remodelling complexes, such as CHRAC, RSF, ACF, NuRD and NoRC. SNF2H is similar in sequence to the Drosophila ISWI chromatin remodelling protein.
- Immunogen: Peptide coupled to keyhole limpet hemocyanin
- Research area: Genetics
- For Research Use Only
Target Details
- Target: SNF2H
- Target molecular weight: 121 kDa
- Target background: SNF2H is a human homolog of the budding yeast Snf2 protein, and is a member of the SWI/SNF family of proteins. The members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. SNF2H is the catalytic subunit of several chromatin remodelling complexes, such as CHRAC, RSF, ACF, NuRD and NoRC. SNF2H is similar in sequence to the Drosophila ISWI chromatin remodelling protein.
Application Details
- Application: ChIP ; IHC ; IF ; IP ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage buffer: Whole serum
- Storage conditions: -15ðC to -25ðC
- Shipping conditions: Shipping at 4ðC
Related Tools
References
- • Mueller et al. 2013. Oncogene. 32(9):1164-72. PMID: 22525276.
- • The miR-99 family regulates the DNA damage response through its target SNF2H.
- • Sacilotto et al. 2011. PLoS One. 6(8):e23318. PMID: 21858068.
- • Epigenetic transcriptional regulation of the growth arrest-specific gene 1 (Gas1) in hepatic cell proliferation at mononucleosomal resolution.
- • Lessard et al. 2010. Mol Cell. 38(4):539-50. PMID: 20513429.
- • The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I.
- • Bozhenok et al. 2002. EMBO J. 21(9):2231-41. PMID: 11980720.
- • WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.