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Contributor Information

  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-TFF1 [PS2GE2]
  • Alternate names: BCEI, Breast Cancer Estrogen Inducible Protein, Gastrointestinal Trefoil Protein, Gastrointestinal trefoil protein pS2, HP1A, HPS2, pNR2, TFF1, Trefoil Factor 1 Human Entrez Gene ID 731 Human SwissProt P4155 Human Unigene 16287 Human Gene Symbol TFF1 Human Chromosome Location 16p11.2
  • Clone: PS2GE2
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 6.5 kDa
  • Application: FACS ; IHC ; IF ; IP ; WB
  • Description: pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours.
  • Immunogen: A synthetic peptide of 28 amino acid residues from the C-terminus of human pS2 protein
  • Isotype: IgG1 kappa
  • Research area: Cancer; Cell biology; Genetics

  • For Research Use Only

Target Details

  • Target: Trefoil factor 1 (TFF1), also known as pS2
  • Target molecular weight: 6.5 kDa
  • Target background: pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours.

Application Details

  • Application: FACS ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Williams R, et al. 1996. Hum Pathol.(12):1259-66.PMID: 8958295