ANTIBODIES
Contributor Information
- Name Alison Goodall
- Institute University College London (UCL)
Tool Details
- Tool name: Anti-Factor VII [RFF-VII/2]
- Clone: RFF-VII/2
- Tool type: Antibodies
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; Fn ; WB
- Description: Factor VII is a 50kDa multi-domain, single chain plasma glycoprotein synthesised in the liver. It is essential for blood coagulation. Factor VII is converted to the active, two chain, serine protease Factor VIIa via cleavage by thrombin, factor Xa, factor IXa or factor XIIa. Factor VIIa converts factor X to factor Xa, which in turn converts prothrombin to thrombin. This monoclonal antibody inhibits human FVII activity and may also be used to immunodeplete FVII from normal plasma.
- Immunogen: Purified human Factor VII
- Isotype: IgG1 kappa
- Research area: Tissue-specific biology
- Myeloma used: P3/NS1/1-Ag4.1
- For Research Use Only
Target Details
- Target: Factor VII
- Target background: Factor VII is a 50kDa multi-domain, single chain plasma glycoprotein synthesised in the liver. It is essential for blood coagulation. Factor VII is converted to the active, two chain, serine protease Factor VIIa via cleavage by thrombin, factor Xa, factor IXa or factor XIIa. Factor VIIa converts factor X to factor Xa, which in turn converts prothrombin to thrombin. This monoclonal antibody inhibits human FVII activity and may also be used to immunodeplete FVII from normal plasma.
Application Details
- Application: ELISA ; Fn ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1mg/ml
- Storage buffer: RPMI + 10% FCS; non-adherent; subculture every 2-3 days; split 1:5
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
Related Tools
References
- • Takase T et al. 1988. J Clin Pathol. 41(3):337-41. PMID: 3360957 Takase T et al. 1988. J Clin Pathol. 41(3):342-5. PMID: 3360958
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