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Contributor Information

  • Name David Becker
  • Institute University College London (UCL)

Tool Details

  • Tool name: Anti-a1 Connexin [1A]
  • Clone: 1A
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Mouse
  • Host: Mouse
  • Application: IHC ; IF ; WB
  • Description: Connexins are a large family of proteins which form gap junctions. Gap junctions are cell membrane structures that facilitate direct cell-cell communication. Gap junction communication has been implicated in the patterning and development of vertebrate embryos. Individual connexins show complex spatial and temporal variation in expression patterns. This variation contributes to the control of intercellular signalling.
  • Immunogen: The peptide, EIKKFKYGIEEH, was coupled at the C-terminal end to bovine thyroglobulin at a final molar ratio peptide:thyroglobulin of 4060:1.
  • Isotype: IgG
  • Research area: Cell signaling and signal transduction; Neurobiology
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: Connexin 43 (Cx43 or a1)
  • Target background: Connexins are a large family of proteins which form gap junctions. Gap junctions are cell membrane structures that facilitate direct cell-cell communication. Gap junction communication has been implicated in the patterning and development of vertebrate embryos. Individual connexins show complex spatial and temporal variation in expression patterns. This variation contributes to the control of intercellular signalling.

Application Details

  • Application: IHC ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Gorbe et al. 2007. Exp Cell Res. 313(6):1135-48. PMID: 17331498.
  • •  Myoblast proliferation and syncytial fusion both depend on connexin43 function in transfected skeletal muscle primary cultures.
  • •  Pearson et al. 2005. J Neurosci. 25(46):10803-14. PMID: 16291954.
  • •  Gap junctions modulate interkinetic nuclear movement in retinal progenitor cells.
  • •  Saitongdee et al. 2004. J Histochem Cytochem. 52(5):603-15. PMID: 15100238.
  • •  Levels of gap junction proteins in coronary arterioles and aorta of hamsters exposed to the cold and during hibernation and arousal.
  • •  Wright et al. 2001. Reproduction. 121(1):77-88. PMID: 11226030.
  • •  Stage-specific and differential expression of gap junctions in the mouse ovary: connexin-specific roles in follicular regulation.