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Contributor Information

  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-ATMIN [ATMIN 11F4]
  • Clone: ATMIN 11F4
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target:
  • Application: IF ; IP ; WB
  • Description: The checkpoint kinase ATM (ataxia telangiectasia mutated) transduces genomic stress signals to halt cell cycle progression and promote DNA repair in response to DNA damage. ATMIN (ATM INteracting protein) is an essential cofactor for ATM. ATMIN interacts with ATM through a C-terminal motif, which is also present in Nijmegen breakage syndrome (NBS) 1.
  • Immunogen: Synthetic peptide
  • Isotype: IgG2a
  • Research area: Genetics
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Ataxia Telangiectasia Mutated Interacting protein (ATMIN, ASCIZ)
  • Target molecular weight:
  • Target background: The checkpoint kinase ATM (ataxia telangiectasia mutated) transduces genomic stress signals to halt cell cycle progression and promote DNA repair in response to DNA damage. ATMIN (ATM INteracting protein) is an essential cofactor for ATM. ATMIN interacts with ATM through a C-terminal motif, which is also present in Nijmegen breakage syndrome (NBS) 1.

Application Details

  • Application: IF ; IP ; WB

Handling

  • Format: Liquid
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -80°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Kanu et al. 2007. EMBO J. 26(12):2933-41. PMID: 17525732.
  • •  ATMIN defines an NBS1-independent pathway of ATM signalling.