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Contributor Information

  • Name Margaret Goodall ; D.L. Hardie ; Roy Jefferis ; Ian MacLennen
  • Institute University of Birmingham

Tool Details

  • Tool name: Anti-CD45 [BU64]
  • Alternate names: Anti-PTPRC
  • Clone: BU64
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Host: Mouse
  • Strain: Balb/c
  • Description: PTPRC, also know as CD45, is a transmembrane tyrosine phosphatase that is present on all leukocytes. It regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn).
  • Isotype: IgG1
  • Research area: Tissue-specific biology; Cell biology; Cell signaling and signal transduction; Immunology; Neurobiology; Stem cell biology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45)
  • Target background: PTPRC is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn).

Application Details

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1mg/ml
  • Storage buffer: RPMI 1640 + 10% FCS
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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