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Contributor Information

  • Name Roy Jefferis
  • Institute University of Birmingham

Tool Details

  • Tool name: Anti-CD70 [BU69] mAb
  • Alternate names: CD7 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD27 Ligand; CD27LG; TNFSF7; CD27L; Tumor Necrosis Factor Ligand 8A; Surface Antigen CD7; Ki-24 Antigen; CD7 Antigen; TNLG8A
  • Clone: BU69
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 30 kDa
  • Application: FACS ; IHC ; IP
  • Strain: Balb/c
  • Description: BU69 inhibits T cell proliferation induced by dendritic cells.
  • Immunogen: Waldenstroms macroglobulineamia cell line WM-1
  • Isotype: IgG1
  • Research area: Apoptosis and autophagy; Cancer; Immunology; Stem cell biology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: CD70
  • Target molecular weight: 30 kDa
  • Target background: CD70 is a 30kDa ligand of the receptor CD27. Both belong to the tumour necrosis factor receptor superfamily 7. Receptor activation can induce proliferation and apoptosis.

Application Details

  • Application: FACS ; IHC ; IP

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Schlossman, S.F. et al. 1995 Leukocyte Typing V Oxford University Press
  • •  Ito et al. 1999. J Immunol. 163(3):1409-19. PMID: 10415041.
  • •  A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells.