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Contributor Information

  • Name Jacqueline Cordell
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-HRX [HRX107]
  • Clone: HRX107
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ChIP ; IHC ; IF ; WB
  • Description: The HRX gene (also called MLL, ALL-1 or Htrx) located to chromosome band 11q23 is associated with specific subsets of acute Lukaemia through translocations that that result in its fusion with a variety of heterologous partners
  • Immunogen: Synthetic peptides corresponding to 839-854 of the HRX protein
  • Isotype: IgM
  • Research area: Cancer; Genetics
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Histone-lysine N-methyltransferase (HRX, MLL, ALL1, Htrx)
  • Target background: The HRX gene (also called MLL, ALL-1 or Htrx) located to chromosome band 11q23 is associated with specific subsets of acute Lukaemia through translocations that that result in its fusion with a variety of heterologous partners

Application Details

  • Application: ChIP ; IHC ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Mueller et al. 2009. PLoS Biol. 7(11):e1000249. PMID: 19956800.
  • •  Misguided transcriptional elongation causes mixed lineage leukemia.
  • •  Butler et al. 1997. Blood. 89(9):3361-70. PMID: 9129043.
  • •  The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures.