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Contributor Information

  • Name Karen Pulford
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-LILRB1 [VMP55]
  • Clone: VMP55
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 120 kDa
  • Application: FACS ; IP ; WB
  • Description: LILRB1 is a 120kD membrane glycoprotein expressed strongly on plasma cells, moderately on circulating B cells and weakly on monocytes. It is not expressed on neutrophils, T cells, NK cells or any non-hematopoietic cells. The functional role of LILRB1 has not been fully elucidated.
  • Immunogen: Hairy cell leukaemia cells
  • Isotype: IgG1 kappa
  • Research area: Immunology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Leukocyte Immunogolobulin-like Receptor subfamily B member 1 (LILRB1, CD85)
  • Target molecular weight: 120 kDa
  • Target background: LILRB1 is a 120kD membrane glycoprotein expressed strongly on plasma cells, moderately on circulating B cells and weakly on monocytes. It is not expressed on neutrophils, T cells, NK cells or any non-hematopoietic cells. The Fn role of LILRB1 has not been fully elucidated.

Application Details

  • Application: FACS ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Lamar et al. 2010. Blood. 115(16):3278-86. PMID: 20194892.
  • •  Promoter choice and translational repression determine cell type-specific cell surface density of the inhibitory receptor CD85j expressed on different hematopoietic lineages.
  • •  Prod'homme et al. 2007. J Immunol. 178(7):4473-81. PMID: 17372005.
  • •  The human cytomegalovirus MHC class I homolog UL18 inhibits LIR-1+ but activates LIR-1- NK cells.
  • •  Banham et al. 1999. J Leukoc Biol. 65(6):841-5. PMID: 10380908.
  • •  Identification of the CD85 antigen as ILT2, an inhibitory MHC class I receptor of the immunoglobulin superfamily.
  • •  Pulford et al. 1991. Clin Exp Immunol. 85(3):429-35. PMID: 1893623.
  • •  A 72-kD B cell-associated surface glycoprotein expressed at high levels in hairy cell leukaemia and plasma cell neoplasms.