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Contributor Information

  • Name Jacqueline Cordell
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-CR1 [To5]
  • Clone: To5
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: FACS ; IHC ; IF ; WB
  • Description: To5 may be used in studies of immune complex mediated glomerulopathies.
  • Immunogen: C3b receptor-enriched precipitates from tonsil cell membranes
  • Isotype: IgG1
  • Research area: Cancer; Immunology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Complement Receptor Type 1 (CR1, CD35)
  • Target background: CR1 is found on many leucocytes and binds C3b and C4b.

Application Details

  • Application: FACS ; IHC ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Kremlitzka et al. 2013. Int Immunol. 25(1):25-33. PMID: 22962438.
  •   Complement receptor type 1 (CR1, CD35) is a potent inhibitor of B-cell functions in rheumatoid arthritis patients.
  •   Gerdes et al. 1982. Immunology. 45(4):645-53. PMID: 7068171.
  •   Human complement (C3b) receptors defined by a mouse monoclonal antibody.
  •   Fearon et al. 1980. J Exp Med. 152(1):20-30. PMID: 6967510.
  •   Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte.
  •   Gerdes et al. 1980. Immunology. 39(1):75-84. PMID: 6991397.
  •   Xenoantiserum to human C3 receptors: its preparation and effect on the C3b and C3d receptors of tonsil cells and the C3b receptors of erythrocytes and neutrophils.