ANTIBODIES

Contributor Information
- Name Jacqueline Cordell
- Institute University of Oxford
Tool Details
- Tool name: Anti-CR1 [To5]
- Clone: To5
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: FACS ; IHC ; IF ; WB
- Description: To5 may be used in studies of immune complex mediated glomerulopathies.
- Immunogen: C3b receptor-enriched precipitates from tonsil cell membranes
- Isotype: IgG1
- Research area: Cancer; Immunology
- Myeloma used: P3/NS1/1-Ag4.1
- For Research Use Only
Target Details
- Target: Complement Receptor Type 1 (CR1, CD35)
- Target background: CR1 is found on many leucocytes and binds C3b and C4b.
Application Details
- Application: FACS ; IHC ; IF ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15ðC to -25ðC
- Shipping conditions: Shipping at 4ðC
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References
- • Kremlitzka et al. 2013. Int Immunol. 25(1):25-33. PMID: 22962438.
- • Complement receptor type 1 (CR1, CD35) is a potent inhibitor of B-cell functions in rheumatoid arthritis patients.
- • Gerdes et al. 1982. Immunology. 45(4):645-53. PMID: 7068171.
- • Human complement (C3b) receptors defined by a mouse monoclonal antibody.
- • Fearon et al. 1980. J Exp Med. 152(1):20-30. PMID: 6967510.
- • Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte.
- • Gerdes et al. 1980. Immunology. 39(1):75-84. PMID: 6991397.
- • Xenoantiserum to human C3 receptors: its preparation and effect on the C3b and C3d receptors of tonsil cells and the C3b receptors of erythrocytes and neutrophils.