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Contributor Information

  • Name Stephen West
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-EME1 [MTA31 7h2/1]
  • Clone: MTA31 7h2/1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 60-65 kDa
  • Application: WB
  • Strain: Balb/c
  • Description: EME1 (aka Msm4) and Mus81 constitute a heterodimeric endonuclease that has been implicated in mitotic and meiotic recombination in eukaryotes.
  • Immunogen: Human EME1
  • Isotype: IgG1
  • Research area: Cell biology; Developmental biology; Stem cell biology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Essential meiotic endonuclease 1 (EME1)
  • Target molecular weight: 60-65 kDa
  • Target background: EME1 (aka Msm4) and Mus81 constitute a heterodimeric endonuclease that has been implicated in mitotic and meiotic recombination in eukaryotes.

Application Details

  • Application: WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Rass et al. 2010. Genes Dev. 24(14):1559-69. PMID: 20634321.
  • •  Mechanism of Holliday junction resolution by the human GEN1 protein.
  • •  Tomoda et al. 2009. Int J Cancer. 124(12):2997-3001. PMID: 19267403.
  • •  Fn evidence for Eme1 as a marker of cisplatin resistance.