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Contributor Information

  • Name Stephen West
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-XRCC2 [XRCC2 1G4/1]
  • Clone: XRCC2 1G4/1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Hamster
  • Host: Mouse
  • Molecular weight of the target: 33 kDa
  • Application: WB
  • Strain: Balb/c
  • Description: X-Ray Repair Cross Complementing 2 (XRCC2) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC2 is also a component of the homologous recombination pathway.
  • Immunogen:
  • Isotype: IgG1
  • Research area: Microbiology; Genetics
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: XRay Repair Cross Complementing 2 (XRCC2)
  • Target molecular weight: 33 kDa
  • Target background: X-Ray Repair Cross Complementing 2 (XRCC2) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC2 is also a component of the homologous recombination pathway.

Application Details

  • Application: WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Gildemeister et al. 2009. J Biol Chem. 284(46):31945-52. PMID: 19783859.
  • •  Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C.
  • •  Nagaraju et al. 2009. Mol Cell Biol. 29(15):4283-94. PMID: 19470754.
  • •  XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversions between sister chromatids.
  • •  French et al. 2002. J Biol Chem. 277(22):19322-30. PMID: 11912211.
  • •  Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability.