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Contributor Information

  • Name Madalena Tarsounas
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-SCP3 [Cor 10G11/7]
  • Clone: Cor 10G11/7
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Hamster ; Mouse ; Zebrafish
  • Host: Mouse
  • Application: IF ; ELISA ; IHC ; IF ; WB
  • Strain: Balb/c
  • Description: Cor 10G11/7 is an excellent tool for the visualisation of chromosomes in meiotic spreads.
  • Immunogen: Hamster COR1/SCP3 protein (expressed as 6x His fusion in bacteria and purified on a Talon under denaturing conditions).
  • Isotype: IgG1 kappa
  • Research area: Cell biology; Genetics
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Synaptonemal Complex Protein 3 (SCP3; COR1)
  • Target background: SCP3 (murine and human) / COR1 (hamster) is a component of the meiotic chromosome cores.

Application Details

  • Application: IF ; ELISA ; IHC ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: DMEM + 5% FCS
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Verver et al. 2013. Cell Death Dis. 4:e749. PMID: 23907463.
  • •  Role for rodent Smc6 in pericentromeric heterochromatin domains during spermatogonial differentiation and meiosis.
  • •  Yamaguchi et al. 2013. Cell Res. 23(3):329-39. PMID: 23399596.
  • •  Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming.
  • •  Heaney et al. 2012. Development. 139(9):1577-86. PMID: 22438569.
  • •  Germ cell pluripotency, premature differentiation and susceptibility to testicular teratomas in mice.
  • •  Tarsounas et al. 2004. Cell. 117(3):337-47. PMID: 15109494.
  • •  Telomere maintenance requires the RAD51D recombination/repair protein.