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Contributor Information

  • Name Giampietro Schiavo
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-Kidins220 [p220 1F8/3]
  • Clone: p220 1F8/3
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Rat
  • Host: Mouse
  • Molecular weight of the target: 220 kDa
  • Application: ELISA ; IHC ; IP ; WB
  • Strain: Balb/c
  • Description: Kidins220/ARMS (Kinase D-Interacting Substrate of 220 kDa, ARMS; Ankyrin Repeat-rich Membrane Spanning) is an integral membrane protein that is selectively expressed in brain and neuroendocrine cells and phosphorylated by PKD (protein Kinase D). Kidins220 has also been shown to function downstream of the Trk and Eph receptor tyrosine kinases.
  • Immunogen: Recombinant GST-Kidins220/ARMS (last 347 amino acids at the carboxy terminus) fusion protein.
  • Isotype: IgG1
  • Research area: Tissue-specific biology; Cell signaling and signal transduction; Neurobiology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Kidins220/ARMS
  • Target molecular weight: 220 kDa
  • Target background: Kidins220/ARMS (Kinase D-Interacting Substrate of 220 kDa, ARMS; Ankyrin Repeat-rich Membrane Spanning) is an integral membrane protein that is selectively expressed in brain and neuroendocrine cells and phosphorylated by PKD (protein Kinase D). Kidins220 has also been shown to function downstream of the Trk and Eph receptor tyrosine kinases.

Application Details

  • Application: ELISA ; IHC ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Deswal et al. 2013. J Immunol. 190(5):1927-35. PMID: 23359496.
  • •  Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells.
  • •  Bracale et al. 2007. Mol Biol Cell. 18(1):142-52. PMID: 17079733.
  • •  Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation.
  • •  Iglesias et al. 2000. J Biol Chem. 275(51):40048-56. PMID: 10998417.
  • •  Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D.