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Contributor Information

  • Name Giampietro Schiavo
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-PIP2 [PIP2 2C11]
  • Clone: PIP2 2C11
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Host: Mouse
  • Application: ChIP ; ELISA ; IHC ; IF ; IP ; Fn ; DB
  • Strain: Balb/c
  • Description: PtdIns 4,5-P2 is a membrane phospholipid and an important component of signal transduction pathways.
  • Immunogen: Liposomes (prepared in PBS with lipid A, phosphatidylcholine (PC) and cholesterol) containing synthetic di-palmitoyl PtdIns(4,5)P2.
  • Isotype: IgM
  • Research area: Cell signaling and signal transduction; Neurobiology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Phosphatidylinositol biphosphate (PIP2)
  • Target background: PtdIns 4,5-P2 is a membrane phospholipid and an important component of signal transduction pathways.

Application Details

  • Application: ChIP ; ELISA ; IHC ; IF ; IP ; Fn ; DB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Toska et al. 2014. Oncogene. 33(43):5100-8. PMID: 24166496.
  • •  Prohibitin is required for transcriptional repression by the WT1-BASP1 complex.
  • •  Ozkucur et al. 2011. BMC Cell Biol. 12:4. PMID: 21255452.
  • •  Persistent directional cell migration requires ion transport proteins as direction sensors and membrane potential differences in order to maintain directedness.
  • •  Osborne et al. 2001. J Cell Sci. 114(Pt 13):2501-11. PMID: 11559758.
  • •  Nuclear PtdIns(4,5)P2 assembles in a mitotically regulated particle involved in pre-mRNA splicing.
  • •  Thomas et al. 1999. Biochem Soc Trans. 27(4):648-52. PMID: 10917659.
  • •  Generation of phosphatidylinositol-specific antibodies and their characterization.