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Contributor Information

  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-HLADRa [TAL 1B5]
  • Clone: TAL 1B5
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 33 kDa
  • Application: IHC ; ELISA ; FACS ; IHC ; IF ; RIA ; WB
  • Description: TAL 1B5 may be used for HLA typing.
  • Immunogen: Bristol 8 separated alpha chain preparation
  • Isotype: IgG1
  • Research area: Immunology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Human Leukocyte Antigen DR, alpha subunit
  • Target molecular weight: 33 kDa
  • Target background: Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D).

Application Details

  • Application: IHC ; ELISA ; FACS ; IHC ; IF ; RIA ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Roher et al. 2013. PLoS One. 8(3):e59735. PMID: 23555764.
  •   Bapineuzumab alters a? composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy.
  •   Chung et al. 2012. Int J Cancer. 131(3):E227-35. PMID: 22174092.
  •   Tumor-associated macrophages correlate with response to epidermal growth factor receptor-tyrosine kinase inhibitors in advanced non-small cell lung cancer.
  •   van Dongen et al. 2010. Int J Cancer. 127(4):899-909. PMID: 20013807.
  •   Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors.
  •   Thomas et al. 1988. J Pathol. 154(4):353-63. PMID: 2455029.
  •   HLA-D region alpha-chain monoclonal antibodies: cross-reaction between an anti-DP alpha-chain antibody and smooth muscle.
  •   Adams et al. 1983. Immunology. 50(4):613-24. PMID: 6197354.
  •   Production and characterization of monoclonal antibodies recognizing the alpha-chain subunits of human ia alloantigens.