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Contributor Information

  • Name Roland Wolf
  • Institute University of Dundee

Tool Details

  • Tool name: Anti-Cytochrome P450 1A2 [D15]
  • Clone: D15
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse ; Rat
  • Host: Mouse
  • Molecular weight of the target: 52 kDa
  • Application: ELISA ; IHC ; IF ; WB
  • Description: In animals, P450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The four major families involved in drug metabolism are CYP 1,2,3, and 4. CYP1A2 is an aryl hydrocarbon hydroxylase involved in the metabolism of endogenous compounds and xenobiotics. It is one of the major drug metabolising enzymes in humans.
  • Immunogen: MC1a (Preparation C31B4, rat liver cytochrome P4501A2)
  • Isotype: IgG1
  • Research area: Cancer; Tissue-specific biology; Cell signaling and signal transduction; Metabolism

  • For Research Use Only

Target Details

  • Target: Cytochrome P450 1A2, CYP1A2
  • Target molecular weight: 52 kDa
  • Target background: In animals, P450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The four major families involved in drug metabolism are CYP 1,2,3, and 4. CYP1A2 is an aryl hydrocarbon hydroxylase involved in the metabolism of endogenous compounds and xenobiotics. It is one of the major drug metabolising enzymes in humans.

Application Details

  • Application: ELISA ; IHC ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Getachew et al. 2010. Biochem Pharmacol. 79(9):1363-71. PMID: 20036646.
  • •  Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice.
  • •  Seibert et al. 2009. J Proteome Res. 8(4):1672-81. PMID: 19714871.
  • •  Multiple-approaches to the identification and quantification of cytochromes P450 in human liver tissue by mass spectrometry.
  • •  Lane et al. 2007. Mol Cell Proteomics. 6(6):953-62. PMID: 17296599.
  • •  Comparative cytochrome P450 proteomics in the livers of immunodeficient mice using 18O stable isotope labeling.