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Contributor Information

  • Name Julian Gannon
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-Cdk1 [Y100.4]
  • Alternate names: Cyclin-Dependent Kinase 1; Cell Division Cycle 2, G1 To S And G2 To M; Cell Division Control Protein 2 Homolog; Cell Division Protein Kinase 1; P34 Protein Kinase; P34CDC2; CDC28A; CDC2; Cell Cycle Controller CDC2; CDKN1
  • Clone: Y100.4
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Schizosaccharomyces pombe
  • Host: Mouse
  • Application: WB ; WB
  • Description: Cdk1 (Cdc2) is a serine/threonine kinase which forms complexes with cyclins A and B which then phosphorylate a variety of target substrates to enable cell cycle progression. Therefore, Cdk1 is a marker for proliferating tumour cells.
  • Immunogen: Peptide spanning the C-terminal 14 residues of S. pombe Cdk1.
  • Isotype: IgG2b
  • Research area: Cancer; Cell biology; Neurobiology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Cyclin Dependent Kinase 1 (Cdk1, Cdc2)
  • Target background: Cdk1 (Cdc2) is a serine/threonine kinase which forms complexes with cyclins A and B which then phosphorylate a variety of target substrates to enable cell cycle progression. Therefore, Cdk1 is a marker for proliferating tumour cells.

Application Details

  • Application: WB ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Mennie et al. 2018. Nat Commun. 9(1):586. PMID: 29422503.
  • •  Chang et al. 2013. PLoS Genet. 9(11):e1003936. PMID: 24244195.
  • •  Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension.
  • •  Radcliffe et al. 1998. Mol Biol Cell. 9(7):1757-71. PMID: 9658169.
  • •  Identification of novel temperature-sensitive lethal alleles in essential beta-tubulin and nonessential alpha 2-tubulin genes as fission yeast polarity mutants.
  • •  Yamano et al. 1996. EMBO J. 15(19):5268-79. PMID: 8895572.
  • •  The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe.