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Contributor Information

  • Name Walter Bodmer
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-Myofibroblast marker [PR 2D3]
  • Clone: PR 2D3
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 140 kDa
  • Application: IP ; WB ; IHC ; IF
  • Strain: Balb/c
  • Description: PR 2D3 reacts with a cell membrane component of cells in the pericrypt sheath; with smooth muscle cells and myofibroblasts. This antibody is considered to be the gold standard for the identification of myofibroblasts.
  • Immunogen: Crude homogenate of normal colorectal mucosa.
  • Isotype: IgG1
  • Research area: Cell biology
  • Myeloma used: NS0

  • For Research Use Only

Target Details

  • Target: Myofibroblast marker
  • Target molecular weight: 140 kDa
  • Target background: PR 2D3 reacts with a cell membrane component of cells in the pericrypt sheath; with smooth muscle cells and myofibroblasts. This antibody is considered to be the gold standard for the identification of myofibroblasts.

Application Details

  • Application: IP ; WB ; IHC ; IF

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Hsia et al. 2016. Proc Natl Acad Sci U S A. :. PMID: 27036009.
  • •  Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers.
  • •  Kirkland et al. 2001. J Cell Sci. 114(Pt 11):2055-64. PMID: 11493641.
  • •  Collagen IV synthesis is restricted to the enteroendocrine pathway during multilineage differentiation of human colorectal epithelial stem cells.
  • •  Richman et al. 1987. J Clin Pathol. 40(6):593-600. PMID: 3301906.
  • •  Colonic pericrypt sheath cells: characterisation of cell type with new monoclonal antibody.