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Contributor Information

  • Name Nancy Hogg
  • Institute Imperial College

Tool Details

  • Tool name: Anti-Integrin alpha 2b + beta 3 [P256]
  • Alternate names: alpha 2B/beta3, alphaIIbetabeta3, GPIIbetabeta3, CD41/CD61, platelet fibronectin receptor
  • Clone: P256
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 135 kDa
  • Application: IHC ; IF ; IP ; WB
  • Strain: Balb/c
  • Description: P256 induces aggregation of normal platelets in plasma.
  • Immunogen: Peripheral blood mononuclear cells
  • Isotype: IgG1
  • Research area: Cell signaling and signal transduction; Cell biology; Extracellular Matrix
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Integrin a2b?3 (CD41 & CD61)
  • Target molecular weight: 135 kDa
  • Target background: Integrins are heterodimeric cell surface receptors composed of a and ? subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a2b (CD41) and integrin ?3 (CD61) associate to form the heterodimer integrin a2bb3 (CD41/CD61; GPIIb/IIIa), a fibronectin receptor expressed in platelets. P256 has potential use for imaging of thrombi.

Application Details

  • Application: IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Activation of platelets induced by mAb P256 specific for glycoprotein IIb-IIIa. Possible evidence for a role for IIb-IIIa in membrane signal transduction.
  • •  1989. Ann. Meeting Br. Nuclear Med. Soc. Abstracts. 243.
  • •  In vivo studies with an anti-platelet monoclonal antibody
  • •  P256.
  • •  Monoclonal antibodies specific for platelet glycoproteins react with human monocytes.