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Contributor Information

  • Name Walter Bodmer
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-Leu1 [H65]
  • Alternate names: CD5 Molecule 2; Lymphocyte Antigen T1/Leu-1; LEU1; CD5 Antigen; T1
  • Clone: H65
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; IF ; IP ; RIA ; WB
  • Strain: Balb/c
  • Description: CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3: it was used as a T-cell marker until monoclonal antibodies against CD3 were developed (see our UCHT1 anti-CD3 antibody). It is found in 76% of T-cells neoplasms, but also in diffuse large B cell lymphoma, chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells. It is commonly lost in cutaneous T-cell lymphoma, and its absence can be used as an indicator of malignancy in this condition.
  • Immunogen: HSB-2 cells.
  • Isotype: IgG1
  • Research area: Immunology; Stem cell biology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Leu1 (CD5)
  • Target background: CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3: it was used as a T-cell marker until monoclonal antibodies against CD3 were developed (see our UCHT1 anti-CD3 antibody). It is found in 76% of T-cells neoplasms, but also in diffuse large B cell lymphoma, chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells. It is commonly lost in cutaneous T-cell lymphoma, and its absence can be used as an indicator of malignancy in this condition.

Application Details

  • Application: IHC ; IF ; IP ; RIA ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  1st International Workshop on Human Leucocyte Differentiation Antigens (CodeT34) Paris. 1982.