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Contributor Information

  • Name John Kemshead
  • Institute Institute of Child Health

Tool Details

  • Tool name: Anti-NCAM [ERIC-1]
  • Alternate names: Neural Cell Adhesion Molecule; NCAM; CD56 Antigen; MSK39
  • Clone: ERIC-1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Neurological cancer; Genitourinary cancer;
  • Molecular weight of the target: 180 kDa, 140 kDa, 120 kDa
  • Application: ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB
  • Strain: Balb/c
  • Description: NCAM, also known as CD56, is a homophillic binding glycoprotein present on a variety of neural cells including neurons, glia, skeletal muscle and natural killer cells. NCAM has been implicated as having a role in cell-cell adhesion, neurite outgrowth, synatptic plasticity, learning and memory and in the development of the nervous system.
  • Immunogen: Retinoblastoma tissue membrane fraction
  • Isotype: IgG1
  • Research area: Cell biology; Cell signaling and signal transduction; Neurobiology; Stem cell biology
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: Neural Cell Adhesion Molecule (NCAM; CD56)
  • Target molecular weight: 180 kDa, 140 kDa, 120 kDa
  • Target background: NCAM, also known as CD56, is a homophillic binding glycoprotein present on a variety of neural cells including neurons, glia, skeletal muscle and natural killer cells. NCAM has been implicated as having a role in cell-cell adhesion, neurite outgrowth, synatptic plasticity, learning and memory and in the development of the nervous system.

Application Details

  • Application: ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Markovic-Lipkovski et al. 2015. PLoS One. 10(9):e0137028. PMID: 26327314.
  • •  Variable Expression of Neural Cell Adhesion Molecule Isoforms in Renal Tissue: Possible Role in Incipient Renal Fibrosis.
  • •  Klehr et al. 2009. J Immunother. 32(5):442-51. PMID: 19609236.
  • •  The novel chimeric anti-NCAM (neural cell adhesion molecule) antibody ch.MK1 displays antitumor activity in SCID mice but does not activate complement-dependent cytolysis (CDC).
  • •  Pruszak et al. 2007. Stem Cells. 25(9):2257-68. PMID: 17588935.
  • •  Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations.
  • •  Blaheta et al. 2004. Neoplasia. 6(4):323-31. PMID: 15256054.
  • •  Human cytomegalovirus infection of tumor cells downregulates NCAM (CD56): a novel mechanism for virus-induced tumor invasiveness.
  • •  Jensen et al. 2003. Clin Exp Immunol. 134(2):253-63. PMID: 14616785.
  • •  The bi-specific CD3 x NCAM antibody: a model to preactivate T cells prior to tumour cell lysis.
  • •  Gerardy-Schahn et al. 1994. Int J Cancer Suppl. 8:38-42. PMID: 7515028.
  • •  Hot spots of antigenicity in the neural cell adhesion molecule NCAM.
  • •  Phimister et al. 1991. J Clin Pathol. 44(7):580-5. PMID: 1856291.
  • •  Expression of neural cell adhesion molecule (NCAM) isoforms in neuroblastoma.
  • •  Frost et al. 1991. Neuropathol Appl Neurobiol. 17(3):207-17. PMID: 1891065.
  • •  Expression of alternative isoforms of the neural cell adhesion molecule (NCAM) on normal brain and a variety of brain tumours.
  • •  Bourne et al. 1991. J Neurooncol. 10(2):111-9. PMID: 1895159.
  • •  A monoclonal antibody (ERIC-1), raised against retinoblastoma, that recognizes the neural cell adhesion molecule (NCAM) expressed on brain and tumours arising from the neuroectoderm.