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Contributor Information

  • Name Lawrence Banks
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-HPV16E6 & HPV18E6 [C1P5]
  • Clone: C1P5
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human papilloma virus
  • Host: Mouse
  • Cancer type: Gynaecologic cancer
  • Molecular weight of the target: 15.8 kDa, 17 kDa
  • Application: IHC ; IP ; WB
  • Strain: Balb/c
  • Description: C1P5 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.
  • Immunogen: Gel-purified HPV-18 E6-beta galactosidase fusion protein
  • Isotype: IgG1
  • Research area: Cancer; Microbiology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Human Papilloma Virus-16 and 18 early protein 6 (HPV16E6 & HPV18 E6)
  • Target molecular weight: 15.8 kDa, 17 kDa
  • Target background: The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively.

Application Details

  • Application: IHC ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.81 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Xie et al. 2014. Oncogene. 33(8):1037-46. PMID: 23474763.
  • •  Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma.
  • •  Herfs et al. 2012. Proc Natl Acad Sci U S A. 109(26):10516-21. PMID: 22689991.
  • •  A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer.
  • •  Lawson et al. 2009. Br J Cancer. 101(8):1351-6. PMID: 19773762.
  • •  Koilocytes indicate a role for human papilloma virus in breast cancer.
  • •  Zhang et al. 2005. J Biol Chem. 280(39):33165-77. PMID: 15983032.
  • •  BRCA1 interaction with human papillomavirus oncoproteins.
  • •  Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140.
  • •  Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.