ANTIBODIES

Contributor Information
- Name Peter Beverley
- Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
- Tool name: Anti-CD45 [C11]
- Alternate names: Anti-PTPRC
- Clone: C11
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Molecular weight of the target: 180-222 kDa
- Application: IHC ; IP
- Strain: Balb/c
- Description: PTPRC, also known as CD45, is a transmembrane tyrosine phosphatase that is present on all leukocytes. It regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). C11 may be used for differential diagnosis of lymphoma and carcinoma and identification of haemopoietic tumours.
- Immunogen: Human lymphocytes
- Isotype: IgG2a
- Research area: Tissue-specific biology; Cell biology; Cell signaling and signal transduction; Immunology; Neurobiology; Stem cell biology
- Myeloma used: P3/NS1/1-Ag4.1
- For Research Use Only
Target Details
- Target: Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45)
- Target molecular weight: 180-222 kDa
- Target background: PTPRC is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). C11 may be used for differential diagnosis of lymphoma and carcinoma and identification of haemopoietic tumours.
Application Details
- Application: IHC ; IP
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15ðC to -25ðC
- Shipping conditions: Shipping at 4ðC
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References
- • Williams et al. 2003. Clin Exp Immunol. 131(1):68-74. PMID: 12519388.
- • Dipeptidyl peptidase IV on activated T cells as a target molecule for therapy of rheumatoid arthritis.