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Contributor Information

  • Name Julian Gannon
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-ADA [ADA-1]
  • Clone: ADA-1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: E.coli
  • Host: Mouse
  • Application: WB ; IHC ; IP ; RIA ; WB
  • Strain: Balb/c
  • Description: Ada is an O6-methylguanine DNA methyltransferase that protects against DNA alkylation by the repair of methylated bases. Ada also functions as a positive regulator of the adaptive response to DNA alkylation damage. Induction of the Ada protein is a sign of environmentally caused mutagenesis in bacteria.
  • Immunogen: ADA protein
  • Isotype: IgG1 kappa
  • Research area: Microbiology; Cancer; Genetics; Metabolism
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: ADA protein
  • Target background: Ada is an O6-methylguanine DNA methyltransferase that protects against DNA alkylation by the repair of methylated bases. Ada also functions as a positive regulator of the adaptive response to DNA alkylation damage. Induction of the Ada protein is a sign of environmentally caused mutagenesis in bacteria.

Application Details

  • Application: WB ; IHC ; IP ; RIA ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  McCormack et al. 2015. Elife. 4:. PMID: 26402460.
  • •  Vaughan et al. 1991. Carcinogenesis. 12(2):263-8. PMID: 1995192.
  • •  Environmental mutagens that induce the adaptive response to alkylating agents in Escherichia coli.