Product Image

Contributor Information

  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-XPG [8H7/XPG]
  • Clone: 8H7/XPG
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 185 kDa
  • Application: IF ; ELISA ; FACS ; IHC ; IF ; IP ; WB
  • Strain: Balb/c
  • Description: XPG is a DNA endonuclease that is essential for the dual incision step of nucleotide excision repair (cleaves 3' of the DNA lesion). XPG might be involved in the DNA replication and repair deficiency syndromes Cockayne Syndrome and Xeroderma pigmentosa.
  • Immunogen: Recombinant human XPG protein produced in baculovirus
  • Isotype: IgG2a
  • Research area: Genetics
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: XPG
  • Target molecular weight: 185 kDa
  • Target background: XPG is a DNA endonuclease that is essential for the dual incision step of nucleotide excision repair (cleaves 3' of the DNA lesion). XPG might be involved in the DNA replication and repair deficiency syndromes Cockayne Syndrome and Xeroderma pigmentosa.

Application Details

  • Application: IF ; ELISA ; FACS ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

Related Tools

Product Image

Anti-3H9 Autoantibody

#157700
Product Image

Anti-Urothelium [LBS17]

#151734
Product Image

Anti-Homogalacturonan [LM20]

#157923

References

  • •  HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome.
  • •  O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.
  • •  Igoucheva et al. 2006. Oligonucleotides. 16(1):94-104. PMID: 16584298.
  • •  Bomgarden et al. 2006. EMBO J. 25(11):2605-14. PMID: 16675950.
  • •  Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling.
  • •  Involvement of ERCC1/XPF and XPG in oligodeoxynucleotide-directed gene modification.
  • •  Arajo et al. 2001. Mol Cell Biol. 21(7):2281-91. PMID: 11259578.
  • •  Strong Fn interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome.
  • •  Evans et al. 1997. EMBO J. 16(3):625-38. PMID: 9034344.
  • •  Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG protein.